A 75 year old male with fever since 10 days and altered swnsorium since 5 days

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A 75 year old male came with complaints of 

  •  fever since 10 days 
  • altered sensorium since 5 days  

HOPI:

Patient was apparently asymptomatic 10 days back and then developed fever which was high grade not associated with chills and rigor.  Then he developed altered sensorium since 5 days he was not able to recognise his family members.

PAST HISTORY:

Not a K/C/O DM, HTN, TB,EPILEPSY, ASTHMA

Has hypo-pigmented patches on b/l lower limbs and b/l nipples since 6 years using herbal medication regularly, itching is present.

PERSONAL HISTORY:

He is Married
He consumes 
  • Mixed diet 
  • sleep is adequate 
  • Appetite normal
  • bowel and bladder movements are regular
  • He Consumes Alcohol twice a week (90ml) since 50 years presently abstinent since 15 days 
  • He smokes beedi 1-2 packs/day since 55 years 
FAMILY HISTORY: no similar complaints in the family.

DAILY ROUTINE: Wakes up early in the morning around 5:00am and then goes to the farm, comes back home at 10:00am has breakfast (Tea and bread or some tiffin), from 10:00am to 6:00pm he stays home takes rest and does house chores. Takes his meals on time (3 meals/day).
Sleeps at 10:00pm and the routine continues.

CLINICAL IMAGES:





GENERAL EXAMINATION:
Patient is conscious ,non-cooperative, not oriented to time, place and person.

Thinly built and nourished.

VITALS:

BP: 120/70mmhg
PR: 90bpm
RR: 20cpm
Temp: 100f

SYSTEMIC EXAMINATION:

RS:
Inspection : barrel shape 
Decreased breath sounds on right side 
Diffuse expiratory wheeze
CVS: s1,s2 no added sounds
P/A: not tender

Pt is altered
GCS - E3V1M6 
Speech - making incomprensible sounds 
Pupils:NSRL
Motor 
Power :  Not moving his left upper limb and lower limb as actively as right side

Tone : Normal
Reflexes : B    T  S   A   K    P 
           R:     -     -   -    -    -    Flexion 
           L :    -     -   -     -    -    Flexion 
Neck rigidity : Present 
Kerning's : Positive 
Brudzski : Negative

PROVISIONAL DIAGNOSIS: ALTERED SENSORIUM UNDER EVALUATION 

INVESTIGATIONS:

On Day1 

ABG: Day 1 at 10:43pm


ABG: Day 1 at 11:51pm












On 3/09/22





LP PROCEDURE 1:

2D ECHO:

TREATMENT:
1.INJ.CEFTRIAXONE 2gm IV/STAT then 1gm IV/BD
2.INJ.IVF DNS 50ml/hr
3.INJ.PANTOP 40mg IV/OD
4.INJ.ZOFER 4mg IV/SOS
5.INJ.OPTINEURON 1AMP IN 100ml NS IV/OD
6.MONITOR VITALS EVERY 6th hrly
7.GRBS MONITORING EVERY 4th 


Day 2

S: fever since 10 days and altered sensorium since 5 days
Presently altered sensorium 

O: pt is conscious,uncooperative,not oriented to time,place and person.
BP: 120/70mmhg
PR: 90bpm
RR: 20cpm
Temp: 98.6f

SYSTEMIC EXAMINATION:
RS:
Inspection : barrel shape 
Decreased breath sounds on right side 
Diffuse expiratory wheeze

CVS: s1,s2 no added sounds

P/A: not tender

CNS:
Pt is altered
GCS - E3V1M6 
Speech - making incomprensible sounds 
Motor 
Power :  Not moving his left upper limb and lower limb as actively as right side
Tone : Normal
Reflexes : B    T  S   A   K    P 
           R:     -     -   -    -    -    Flexion 
           L :    -     -   -     -    -    Flexion 
Neck rigidity : Present 
Kerning's : Positive 
Brudzski : Negative

A: ?Altered sensorium under evaluation
?Alcohol withdrawal syndrome 

P:
1.INJ.CEFTRIAXONE 2gm IV/STAT then 1gm IV/BD
2.INJ.IVF DNS 50ml/hr
3.INJ.PANTOP 40mg IV/OD
4.INJ.ZOFER 4mg IV/SOS
5.INJ.OPTINEURON 1AMP IN 100ml NS IV/OD
6.MONITOR VITALS EVERY 6th hrly
7.GRBS MONITORING EVERY 4th hrly

INVESTIGATIONS:

ABG: Day 2 at 6:17 am






ABG: Day 2 at 4:46pm


Plan: Patient intubated on ACMV VC MODE as he was hypoxic Post Intubation Ventilator Settings : 
RR - 16
Fio2 - 40
PEEP - 5 
TV - 400

Post Intubation Vitals :
Pupils - B/L Fixed Pin point Pupils 
BP - 100/70mmHg 
PR - 116/Min 
RR - 22/Min 
Spo2 - 100%

Midaz Infusio - 5ml/hr
Atracurium Infusion - 10ml/hr

ABG:Day 2 at 9:50pm



Day 3

S:pt is on mechanical ventilator and sedation 

O: pt on SIMV VC mode
RR TOTAL: 29
RR:20
Fio2:30%
PEEP: 5 cm of H2O
TV:400

VITALS:
BP: 110/70mmhg
PR: 82bpm
RR: 16cpm
Temp: 98.5f

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender

A: Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD.

P:
TREATMENT:
1.INJ.CEFTRIAXONE 2gm IV/STAT then 1gm IV/BD
2.RT FEEDS 100ml milk 4th hrly, 50ml water 2nd hourly 
3.INJ.PANTOP 40mg IV/OD
4.INJ.ZOFER 4mg IV/SOS
5.INJ.OPTINEURON 1AMP IN 100ml NS IV/OD
6.Inj.NEOMOL IV if TEMP>102f sos
7.GRBS MONITORING EVERY 4th hrly
8.Inj.MIDAZ 5ml/hr
9.Tab. Azithromycin 500mg PO/OD





ABG: Day 3 at 5:24 Am




CT SCAN BRAIN:


ABG: Day 3 at 7:20 Am





Day 3 At 9:30 am 
Pt was able to breath on its own so the changes were done to SIMV -VC Mode 
RR Total - 29
RR - 16
Fio2 - 30 
PEEP - 5 
VT - 400

Vitals - 
BP - 100/80
RR - 38/min
HR - 108/min
Spo2 - 97

ABG: Day 3 at 12:20pm


ABG: Day 3 at 9:20pm





On Day 4

S:pt is on mechanical ventilator and sedation 

O: pt on SIMV VC mode
RR TOTAL: 29
RR:20
Fio2:30%
PEEP: 5 cm of H2O
TV:400

VITALS:
BP: 110/70mmhg
PR: 97bpm
RR: 16cpm
Temp: 97.6f

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender

A: Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD.

P:
TREATMENT:
1.INJ.CEFTRIAXONE 2gm IV/STAT then 1gm IV/BD
2.RT FEEDS 100ml milk 4th hrly, 50ml water 2nd hourly 
3.INJ.PANTOP 40mg IV/OD
4.INJ.ZOFER 4mg IV/SOS
5.INJ.OPTINEURON 1AMP IN 100ml NS IV/OD
6.Inj.NEOMOL IV if TEMP>102f sos
7.GRBS MONITORING EVERY 4th hrly



ABG: Day 4 At 9:00am 





CULTURE REPORT:



ABG: Day 4 at 1:36pm



...
ABG: Day 4 at 10:36pm




ABG: Day 5 at 6:30am


Day 5

S:pt is on mechanical ventilator and sedation 

O: pt on SIMV VC mode
RR TOTAL: 34
RR:16
Fio2:21%
PEEP: 5 cm of H2O
TV:400

VITALS:
BP: 130/70mmhg
PR: 122bpm
RR: 20cpm
Temp: 100.8f
SpO2: 97%
GRBS: 327 mg/dl

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender
CNS:
Doll’s eye reflex +
Pt is unresponsive
GCS - E1VTM1
Pupils:B/L equal constricted and reacting to light.
                          R          L
Corneal            +          +
Conjunctival.   +.         +
Tone : Hypotonia
Reflexes : B    T  S   A   K    P 
           R:     -     -   -    -    -    Flexion 
           L :    -     +   -     -    -   Flexion



A: Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD.

P:
TREATMENT:
1.INJ.CEFTRIAXONE 2gm IV/STAT then 1gm IV/BD
2.RT FEEDS 100ml milk 4th hrly, 50ml water 2nd hourly 
3.INJ.PANTOP 40mg IV/OD
4.INJ.ZOFER 4mg IV/SOS
5.INJ.Dexamethasone 4mg BD
6.Inj.NEOMOL IV if TEMP>102f sos
7.GRBS MONITORING EVERY 4th hrly
8.INJ.Clexane 40mg S/C OD
9.Tab. Azithromycin 500mg PO/OD
10.NEB BUDECORT 12th hrly DUOLINE 8th hourly 
11.Monitor vitals



......
Day 5 at 3:50pm


Day 6

S:pt removed from ventilation and was put on T. Piece since today morning 7.30 am 

O:
Pt conscious 
GCS:E4VTM4
spontaneous eye opening + 
Spontaneous breathing +

VITALS:
BP: 120/70mmhg
PR: 137bpm
RR: 30cpm
Temp: 101.3f
SpO2: 98%
GRBS: 197 mg/dl at 8:00am

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender,Soft

A: fever with Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD.

P:
Plan to extubate



ABG: Day 6 at 6:20am


ABG: Day 6 at 9:30am



Urine culture report:





Day 7

S:pt extubated yesterday at 4:00pm
Bed sores at sacral area

O:
Pt conscious 
GCS: E4V5M3
spontaneous eye opening + 
Spontaneous breathing +

VITALS:
BP: 120/70mmhg
PR: 98bpm
RR: 33cpm
Temp: 98.7f
SpO2: 98%
GRBS: 335 mg/dl at 8:00am

CSF reports awaiting 
URINE CULTURE: 
isolated E.coli sensitive to :
Nitrofurantoin
Gentamicin 
Cotrimoxazole
Fosfomycin
Amikacin
Tazobactum
Clavulenic acid
Meropenam

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender,Soft
RS:BAE+

A: fever with Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD, BED SORES + (sacral area Grade II)

P:
RT FEEDS 100ml milk 4th hrly, 50ml water 2nd hrly
Inj.PAN 40mg/IV/OD
Inj.Zofer 4mg/IV/SOS
Inj.Neomol 1gm/IV/TEMP>102f
Neb with budecort 12th hrly, duoline 8th hourly
Frequent change of position every 2nd hrly

Procedures: LP Procedure done at 8:00am today




ABG:Day 7 at 6:00pm











Day 8

S:
Bed sores at sacral area

O:
Pt conscious 
GCS: E4V5M3
spontaneous eye opening + 
Spontaneous breathing +

VITALS:
BP: 120/70mmhg
PR: 92bpm
RR: 22cpm
Temp: 98.5f
GRBS: 345mg/dl at 8:00am

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender,Soft
RS:BAE+

A: fever with Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD, BED SORES + (sacral area Grade II)

P:
RT FEEDS 100ml milk 4th hrly, 50ml water 2nd hrly
Inj.PAN 40mg/IV/OD
Inj.Zofer 4mg/IV/SOS
Inj.Neomol 1gm/IV/TEMP>102f
Neb with budecort 12th hrly, duoline 8th hourly
Frequent change of position every 2nd hrly

ABG: day 8 at 6:00am



......
Day 9

S:
Bed sores at sacral area

O:
Pt conscious 
GCS: E4V5M3
spontaneous eye opening + 
Spontaneous breathing +

VITALS:
BP: 120/70mmhg
PR: 92bpm
RR: 22cpm
Temp: 98.5f
GRBS: 345mg/dl at 8:00am

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender,Soft
RS:BAE+

A: fever with Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD, BED SORES + (sacral area Grade II)

P:
RT FEEDS 100ml milk 4th hrly, 50ml water 2nd hrly
Inj.PAN 40mg/IV/OD
Inj.Zofer 4mg/IV/SOS
Inj.Neomol 1gm/IV/TEMP>102f
Neb with budecort 12th hrly, duoline 8th hourly
Frequent change of position every 2nd hrly




ABG: day 9 at 8:00am






Day 10

S:
Bed sores at sacral area
Dressing is done

O:
Pt conscious 
GCS:E4V4M3
VITALS:
BP: 110/70mmhg
PR: 96bpm
RR: 30cpm
Temp: 98.5f
GRBS: 195mg/dl at 8:00am

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender,Soft
RS:BAE+

A: fever with Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD, BED SORES + (sacral area Grade II)

P:
Mobilise him with support 
RT FEEDS 100ml milk 4th hrly, 50ml water 2nd hrly
Inj.PAN 40mg/IV/OD
Inj.Zofer 4mg/IV/SOS
Inj.Neomol 1gm/IV/TEMP>102f
Neb with budecort 12th hrly, duoline 8th hourly
Frequent change of position every 2nd hrly

Day 11

S:
Bed sores at sacral area grade 2-3 

O:
Pt conscious 
GCS:E4M6V3
VITALS:
BP: 110/70mmhg
PR: 94bpm
RR: 26cpm
Temp: 98F
GRBS: 235mg/dl at 8:00am

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender,Soft
RS:BAE+

A: fever with Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD, BED SORES + (sacral area Grade II)

P:
Mobilise him with support 
RT FEEDS 100ml milk 4th hrly, 50ml water 2nd hrly
Inj.PAN 40mg/IV/OD
Inj.Zofer 4mg/IV/SOS
Inj.Neomol 1gm/IV/TEMP>102f
Neb with budecort 12th hrly, duoline 8th hourly
Frequent change of position every 2nd hrly



Day 12

S:
Bed sores at sacral area grade 2-3 
Irrelevant talk
O:
Pt conscious, not oriented to time,person
GCS:E4M6V3
VITALS:
BP: 110/70mmhg
PR: 82bpm
RR: 26cpm
Temp: 98.6f
GRBS: 124 mg/dl at 8:00am

SYSTEMIC EXAMINATION:
CVS: s1,s2 no added sounds
P/A: not tender,Soft
RS:BAE+

A: fever with Altered sensorium secondary to meningitis with type 1 respiratory failure with acute exacerbation of COPD, BED SORES + (sacral area Grade II)

P:
Mobilise him with support 
Inj.PAN 40mg/IV/OD
Inj.Zofer 4mg/IV/SOS
Inj.Neomol 1gm/IV/TEMP>102f
Neb with budecort 12th hrly, duoline 8th hourly
Frequent change of position every 2nd hrly with ambulation.




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